Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

In this paper, I defend an account of the reasons for which we act, believe, and so on for any Ф such that there can be reasons for which we Ф. Such reasons are standardly called motivating reasons. I argue that three dominant views of motivating reasons (psychologism, factualism and disjunctivism) all fail to capture the ordinary concept of a motivating reason. I show this by drawing out three constraints on what motivating reasons must be, and demonstrating how each view (...) fails to satisfy at least one of these constraints. I then propose and defend my own account of motivating reasons, which I call the Guise of Normative Reasons Account. On the account I defend, motivating reasons are propositions. A proposition is the reason for which someone Ф‐s when (a) she represents that proposition as a normative reason to Ф, and (b) her representation explains, in the right way, her Ф‐ing. As I argue, the Guise of Normative Reasons Account satisfies all three constraints on what motivating reasons must be, and weathers several objections that might be leveled against propositionalist views. (shrink)

The sympathetic plot—featuring a goal-directed protagonist who confronts obstacles, overcomes them, and wins rewards—is ubiquitous. Here, I propose that it recurs because it entertains, engaging two sets of psychological mechanisms. First, it triggers mechanisms for learning about obstacles and how to overcome them. It builds interest by confronting a protagonist with a problem and induces satisfaction when the problem is solved. Second, it evokes sympathetic joy. It establishes the protagonist as an ideal cooperative partner pursuing a goal, appealing to mechanisms (...) for helping. When the protagonist succeeds, they receive rewards, and audiences feel sympathetic joy, an emotion normally triggered when beneficiaries triumph. The capacities underlying the sympathetic plot evolved for learning and cooperation before being co-opted for entertainment. (shrink)

Business ethics has been described as a prime academic growth industry. This paper reports the findings of a survey aimed at establishing the status of ethics in the curricula of Canadian Schools of Management and Administrative Studies. It was found that twenty-three of the forty-two responding schools offer courses in business ethics and that they offer a total of twenty-five ethics courses, twenty of which are offered as electives. Forty-two percent of the schools not offering a course in business ethics (...) plan to offer such a course by 1989. This means that by 1989 seventy-four percent of the responding schools should have a business ethics component in their curricula. (shrink)

In Aesthetic Theory, Adorno discusses the progressive spiritualization of art over the course of two centuries. By excluding natural beauty, art established itself as a realm of freedom created by the autonomous subject. Yet, similar to the process of rationalization that Adorno and Horkheimer describe in the Dialectic of Enlightenment, spiritualization also exposes the autonomy of art to the return of the repressed. In this paper, I establish a distinction in Adorno's work between spiritualization in its traditional sense, which designates (...) this cycle of repression and return, and spiritualization in its radical sense, as the process that turns art against its history of domination. Spiritualization in this latter sense is the basis for an encounter with the repressed that exhibits a non- dominating stance toward otherness. (shrink)

Ethical guidance in research is underpinned by the need to show respect for study participants by upholding autonomy in participant decision-making, and confidentiality and protection of individual rights, privacy and interests, yet decision-making could also be influenced by the participant’s sociocultural and belief systems. This calls for a more Africanised approach to research ethics where these values and beliefs are upheld. While national and international ethics guidelines do exist, there is little evidence that such a paradigm shift in research ethics (...) is adequately interrogated in the teaching and learning curricula in higher education, where research skills are developed and nurtured. Critical reflection is used to highlight opportunities to stimulate learning and debates underpinned by humanised pedagogy in higher education. (shrink)

In recent years, the National Crime Records Bureau recommendation is that the growth rate of crime against women has skyrocketed in India, even higher than the population growth rate. According to lawyer, Kamlesh Vaswani, the commercial exploitation of coital activity paramount in pornography is the result of crimes against women, and fills perverse traits in the roots of society. Following that, he filed a petition (2013) in the Honourable Supreme Court to blanket ban pornography with the aim of diluting the (...) subordination of women and the crimes against women in society. Taking this into consideration, I argue that the Vaswani petition draws back the issue of twentieth century Western political and philosophical debate on pornography which triggers one of the moot problems of moral legislation—whether the state should be neutral or not towards individuals’ preferences, merits, desires, and the status to live well. This article focuses on whether this discourse has any relevance in the Indian value system. In this article, through the comparison between Indian and Western values, I make an attempt to analyse the moot problem of moral legislation which is bridging the gap between public and private morality for the well-being of women as well as our society. (shrink)

This book critically analyses the "mutual illuminations" between literature, religion, architecture, films, performative arts, paintings, woodworks, memes and masks cutting across time and space. In architecture for example, the eventual success of a project depends on the harmony between physical sciences and aesthetics, design and planning, knowledge of building material, the local climate, and awareness of cultural sensibilities. This volume affirms that aesthetics and arts are deeply linked through existential issues of who I am. The essays in this volume present (...) diverse discursive structures showcasing the in-between spaces between various art forms and mediums, such as, architecture, literature and memory, Kafka in SoHo; Kafka and Bernhard, Kirchner's woodcuts; pictorial and stage representations of E.T.A Hoffmann, Hesse's fairy tales; translations of Pañcatantra; Nietzsche, ritual arts and face masks; martyrdom in La chanson de Roland, Goethe and Hafiz, Indian thought in Martin Buber; Rhythms of the 'Third' across cultures; Dadaism and contemporary memes This book examines these sublime linkages in a comparative and interdisciplinary way. Engaging and intersectional, this volume will appeal to students and scholars of arts and aesthetics, literature, philosophy, architecture, sociology, translation studies and readers who are interested in cultural, intertextual, intermedial, and comparative studies. (shrink)

An attempt has been made in this paper to trace Gandhi's principle of 'nonviolence' in the context of 'Enlightenment Rationality' on the one hand and 'Globalization' on the other. The ideas of freedom/independence, autonomy, sovereignty, property, maturity/adulthood, public and private, tolerance, scientific rationality, secularism, humanism, democracy, nation/ state, universality of moral actions, humanity as an end in itself, critique of religion, etc., are the most operative terms of European Enlightenment of the 19th century. Though these ideas evolved and developed in (...) Europe, yet they proliferated beyond Europe to other continents and subcontinents. Gandhi appreciated these ideas and like a genius, he interpreted them into indigenous concepts and principles such as truth, simplicity, faith, brahmacharya, purushartha, satyagraha, swaraj, karma, compassion, trusteeship, vegetarianism/fruitarianism and above all nonviolence with the aim of attaining swaraj - victory over one's passions, lusts, greed, etc., and independence and sovereignty of the country. I may point out, though I shall not be in a position to develop it here, that the basic concepts of the Enlightenment were questioned and repudiated by Marx, Engels and Lenin on the one hand and the critical theorists like Adorno, Horkheimer, Marcuse and Habermas on the other. In the era of globalization, the Enlightenment concepts have become almost obsolete. But Gandhi's principles are still valid. These are the only viable principles to resolve moral dilemmas that everybody faces, being constantly confronted by equally valid alternatives in globalization. Hence I'll propose a modest critique of the Enlightenment and the globalization from Gandhi's perspective of nonviolence. (shrink)

Innovation of Yoga in vedic saṁhitās -- Elaboration of yogic thought and practices in Brāhmaṇas, Āraṇyakas and Upaniṣads -- Continuation of the tradition in the Rāmāyaṇa and the Mahābhārata -- Deviation from the vedic tradition in Jainism and Buddhism -- Systematization of Yoga in Patañjali and Haṭha-yoga -- Yoga of Vedāntic ācāryas and yoga-vāsiṣṭha -- Bhakti-yoga of medieval saints -- Yogic sādhanā in Tantra, Śaivism and Sufism -- Revival of the spirit of Yoga in modern India -- Yogic capability in (...) the estimation of logic. (shrink)

Teachings of the various leaders of the Radhasoami Satsang.

An introduction to Heidegger’s philosophy through a specific elucidation of the problems of the world-concept and death through his early and later thought as well as the connection of these problems with all the other important issues in this thinker’s system, such as existence, ground, art and artworks, language, and dwelling.

There is an alarming trend in the field of medicine, whose portents are ominous but do not seem to shake the complacency and merry making doing the rounds. The wants of the medical man have multiplied beyond imagination. The cost of organizing conferences is no longer possible on delegate fees. The bottom-line is: Crores for a Conference, Millions for a Mid-Term. However, the problem is that sponsors keep a discreet but careful tab on docs. All in all, costs of medicines (...) escalate, and quality medical care becomes a luxury. The whole brunt of this movement is borne by the patient. Companies like GlaxoSmithKline, Bayer, Pfizer, Bristol-Myers Squibb, AstraZeneca, Schering-Plough, Abbott Labs, TAP Pharmaceuticals, Wyeth and Merck have paid millions of dollars each as compensation in the last few years. The financial condition of many pharmaceutical majors is not buoyant either. Price deflation, increased Rand D spending, and litigation costs are the main reasons. In the future, the messy lawsuits situation would no longer be restricted to industry. It would involve academia and practising doctors as well. Indian pharma industry captains, who were busy raking in the profits at present, would also come under the scanner. If nothing else, it means industry and docs will have to sit down and do some soul searching. Both short and long-term measures will have to be put into place. Short-term measures involve reduction in i) pharma spending over junkets and trinkets; ii) hype over 'me too' drugs; iii) manipulation of drug trials; iv) getting pliant researchers into drug trials; iv) manipulation of Journal Editors to publish positive findings about their drug trials and launches; v) and for Indian Pharma, to conduct their own unbiased clinical trial of the latest drug projected as a blockbuster in the West, before pumping in their millions. The long-term measures are related to the way biomedical advance is to be charted. We have to decide whether medicine is to become a corporate enterprise or remain a patient welfare centered profession. A third approach involves an eclectic resolution of the two. Such amount of patient welfare as also ensures profit, and such amount of profit as also ensures patient welfare is to be forwarded. For, profit, without patient welfare, is blind. And patient welfare, without profit, is lame. According to this approach, medicine becomes a patient welfare centered professional enterprise. The various ramifications of each of these approaches are discussed in this monograph. (shrink)

The aim of this article was to discuss the modeling and control method of quadrotor unmanned aerial vehicle. In the process of modeling, mechanism modeling and experimental testing are combined, especially the motor and propeller are modeled in detail. Through the understanding of the body structure and flight principle of the quadrotor UAV, the Newton–Euler method is used to analyze the dynamics of the quadrotor UAV, and the mathematical model of the UAV is established under the small angle rotation. Process (...) identifier is used to control it. First, the attitude angle of the model is controlled by PID, and based on this, the speed in each direction is controlled by PID. Then, the PID control of the four rotor aircraft with the center of gravity offset is simulated by MATLAB. The results show that the pitch angle and roll angle can be controlled by 5 degrees together without center of gravity deviation, and the PID can effectively control the control quantity and achieve the desired effect in a short time. Classical BP algorithm, classical GA-BP algorithm, and improved GA-BP algorithm were trained, respectively, with a total of 150 sets of training data, training function uses Levenberg-Marquardt, and performance function uses mean squared error. In the background of the same noise, the improved GA-BP algorithm has the highest detection rate, classical GA-BP algorithm is the second, and classical BP algorithm is the worst. The simulation results show that the PID control law can effectively control the attitude angle and speed of the rotor UAV in the case of center of gravity deviation. (shrink)

Contribution of Hindu saints of medieval period to Hindu philosophy.